This is a disorder with an invariably lethal course that is resistant to all possible forms of therapeutic intervention and evokes many theories. At a microscopic level, several cell systems in different organs seem to be affected in ALS, which lends support to the concept of ALS as a multi system disorder. Neurodegenerative disorders account for an increasing morbidity worldwide. Motor neurons control muscle movements, breathing, speaking, chewing and swallowing. The upper motor neurons, located in the brain, send nerve impulses to the lower motor neurons in the brain stem and spinal cord.